Abstract: In order to enhance the precision and intelligence level of relay protection in underground coal mine power systems, this paper systematically analyzes and verifies the application of a relay protection setting calculation system (RPSCS) in mine power supply management. By integrating key technologies such as dynamic topology sensing, adaptive setting, equipment status correction, multi-principle coordination, and digital twin simulation, the system achieves intelligent calculation and dynamic optimization of protection settings. The results show that RPSCS significantly improves the sensitivity, selectivity, and reliability of relay protection configuration, meeting the high safety and flexibility demands of modern coal mine power supply management.