Abstract: The operational stability of the high-voltage power distribution system in drainage pumping stations affects the effectiveness of flood control and disaster reduction. The scientific nature of its device selection and configuration is directly related to the efficiency of the pumping station. Based on the actual situation, select the core equipment of the high-voltage distribution device, including the selection of high-voltage circuit breakers, disconnectors and grounding switches, and transformers (current and voltage). The design of high-voltage distribution equipment system configuration mainly includes the configuration of main wiring forms, relay protection system configuration, and operating power supply system configuration. Through the configuration of lightning protection and overvoltage protection, the design of heat dissipation and ventilation systems, and the application configuration of energy-saving equipment, the safety and energy efficiency of high-voltage distribution devices can be optimized. Taking project A as an example, a quantitative analysis is conducted on the selection and configuration of high-voltage distribution equipment for the drainage pumping station to provide support for the efficient operation of the drainage pumping station.