Abstract: To address the grounding challenges caused by high soil resistivity in desertified areas of northwest China’s wind- solar energy bases, this paper takes a photovoltaic and storage collection station as a case study and conducts systematic research on its grounding grid design. Using the CDEGS software, a preliminary grounding grid layout was developed. The study focuses on analyzing the influence of two key factors- non-uniform spacing of grounding grid conductors and variation in grounding well depth-on critical safety parameters such as grounding resistance, ground potential rise, touch voltage, and step voltage. Building on this analysis, and in combination with the actual layout of the photovoltaic and storage collection station, the preliminary design was further optimized for engineering practicality. A comprehensive safety verification was then performed on the optimized grounding grid. The results show that all safety parameters of the final design meet the relevant standards and specifications. The research demonstrates that the proposed approach-automated preliminary design using professional software followed by project-specific optimization-provides an effective way to achieve a safe, reliable, and economical grounding system in high-resistivity soil regions.